All ic bfm 2002 protocol pdf

Rez bfm 2002 by nov 2010, 830 relapses were registered. A retrospective singlecenter study from olomouc, czech republic. The all icbfm 2002 trial is a good example of international collaboration in pediatric oncology. The treatment is very similar to that in the all icbfm 2002 study11 and is described in table 2. The all icbfm 2002 protocol was created as an alternative to the mrdbased aieopbfm all 2000 study, to integrate early response. In sr, protocol iii was repeated twice 12 weeks apart in the. Jan trka, laboratory of molecular genetics, 2 nd dept. This concept drove the design of the all icbfm 2002 trial to be conducted in.

Pdf minimal residual disease mrd analysis in the non. All bfmaieop all2000 relapsed all all rez bf m2002 dclsg all9 interfant 99 mrcall 9799 ukallr3 coall0697 fralle 2000 eortcclg 58951 nopho all2000 prebmt all adult all gmall 0699 adult all lala 2000 adult all ukall xii adult all pethema geth by. Longterm results of the childrens cancer group studies for childhood acute lymphoblastic leukemia 19832002. The all icbfm 2002 protocol was created as an alternative to the mrdbased aieopbfm all 2000 study, to integrate early response criteria into riskgroup stratification in countries not. The new study protocol all ic bfm 2009 is the final result of very comprehensive data analyses and discussions over the last few years. Conclusion the all icbfm 2002 trial is a good example of international collaboration in pediatric oncology. Riskadapted stratification and treatment of childhood all. The treatment of childhood acute lymphoblastic leukemia in. This treatment differs from the all icbfm 2002 protocol as follows.

Sr, two 4week intensive elements protocol iii versus one 7week protocol ii. Clinical research performed within the all ic bfm group but also in parallel in the context of trial aieop bfm all 2000 produced. Awideplatformofcountriesabletorunrandomizedstudiesinallhasbeenestablished. In 2014, the bfm group published their experience with the bfm. Minimal residual disease mrd analysis in the nonmrdbased. The protocol allrez bfm 2002 aims at the optimization of treatment for children with relapsed acute lymphoblastic leukemia. From 2002 to 2007, the international berlinfrankfurtmunster study group conducted a prospective randomized clinical trial all icbfm 2002 for the management of childhood acute lymphoblastic leukemia all in 15 countries on three continents. Allicbfm 2002 protocol in the institute of hematology and. Intensive chemotherapy for childhood acute lymphoblastic. Bfm all 2000 for childhood acute lymphoblastic leukemia. Pdf intensive chemotherapy for childhood acute lymphoblastic. Treatment and prognosis of childhood acute lymphoblastic leukemia on protocols allbfm 90, 95 and all icbfm 2002.

The characteristics of the patients treated with the successive allbfm 90, allbfm 95 and all icbfm 2002 protocols are depicted in table 1distribution of patients according to the major. The primary objective of study allrez bfm 2002 is the randomized comparison of a lower dosed and less intensive, but continuous consolidation therapy with conventional therapy administered in treatment blocks. The aim of this trial was to explore the impact of differential delayed intensification di on outcome in all risk groups. All icbfm 2002 may 2002 1 all icbfm 2002 a randomized trial of the ibfmsg for the management of childhood nonb acute lymphoblastic leukemia final version of therapy protocol from may 3, 2002 start 01. Intensive chemotherapy for childhood acute lymphoblastic leukemia. Although the alternative di did not improve outcome compared with standard treatment and the overall.